Publications about our technology

Methylomics discovered two proprietary pan-gynecological markers and developed a MeD-Scan assay for the rapid detection of all types of gynecological cancer. Three validation studies, showing the remarkably high sensitivity of the MeD-Scan assay, will be published in Q2 2024, along with the patent application for these markers.

Can we use a simple blood test to reduce unnecessary adverse effects from radiotherapy by timely identification of radiotherapy-resistant rectal cancers? MeD-Seq rectal study protocol BMC Cancer. 2023 Dec 23, 1187

Hypermethylation of DNA Methylation Markers in Non-Cirrhotic Hepatocellular Carcinoma Cancers (Basel). 2023 Sep 28;15(19):4784

Liquid Biopsies for Colorectal Cancer and Advanced Adenoma Screening and Surveillance: What to Measure? Cancers (Basel). 2023 Sep 17;15(18):4607

Genome-wide analysis toward the epigenetic aetiology of myelodysplastic syndrome disease progression and pharmacoepigenomic basis of hypomethylating agents drug treatment response Hum Genomics. 2023 Apr 25;17(1):37

Methylated Cell-Free DNA Sequencing (MeD-seq) of LpnPI Digested Fragments to Identify Early Progression in Metastatic Renal Cell Carcinoma Patients on Watchful Waiting Cancers (Basel). 2023 Feb 21;15(5):1374

Retrospective analysis of enhancer activity and transcriptome history Nat Biotechnol. 2023 Feb 23

Kidney Organoids Are Capable of Forming Tumors, but Not Teratomas Stem Cells. 2022 Jun 22;40(6):577-591

Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells Stem Cell Reports. 2022 Mar 8;17(3):693-706

Genome-wide aberrant methylation in primary metastatic UM and their matched metastases Sci Rep. 2022 Jan 7;12(1):42

High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments Clin Epigenetics. 2021 Oct 20;13(1):196

CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells Nat Cell Biol. 2021 Aug 23(8):881-893

Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus Clin Epigenetics. 2021 Jul 29;13(1):148

Differentially Methylated Regions in Desmoid-Type Fibromatosis: A Comparison Between CTNNB1 S45F and T41A Tumors Front Oncol. 2020 Oct 29;10:565031

Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation PLoS Pathog. 2020 Jun 24;16(6):e1008555

Cystic renal-epithelial derived induced pluripotent stem cells from polycystic kidney disease patients Stem Cells Transl Med. 2020 Apr 9(4):478-490

MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma PLoS One. 2020 Jan 23;15(1):e0228014

Gestational jet lag predisposes to later-life skeletal and cardiac disease Chronobiol Int. 2019 May 36(5):657-671

Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion Epigenetics Chromatin. 2018 Aug 31;11(1):50

Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI Genome Res. 2018 Jan 28(1):88-99

Cancer risk stratification of anal intraepithelial neoplasia in HIV-positive men by validated methylation markers associated with progression to cancer. Clin Infect Dis. 2021 Jun 15;72(12):2154-2163

Methylation markers FAM19A4 and miR124-2 as triage strategy for primary human papillomavirus screen positive women: A large European multicenter study Int J Cancer. 2021 Jan 15;148(2):396-405

FAM19A4/miR124-2 methylation in invasive cervical cancer: A retrospective cross-sectional worldwide study Int J Cancer. 2020 Aug 15;147(4):1215-1221

Expression of p16 and HPV E4 on biopsy samples and methylation of FAM19A4 and miR124-2 on cervical cytology samples in the classification of cervical squamous intraepithelial lesions Cancer Med. 2020 Apr 9(7):2454-2461

Intra- and inter-laboratory agreement of the FAM19A4/mir124-2 methylation test: Results from an international study Clin Lab Anal. 2019 May 33(4):e22854

Host Cell Deoxyribonucleic Acid Methylation Markers for the Detection of High-grade Anal Intraepithelial Neoplasia and Anal Cancer Clin Infect Dis. 2019 Mar 19;68(7):1110-1117

Reliable identification of women with CIN3+ using hrHPV genotyping and methylation markers in a cytology-screened referral population Int J Cancer. 2019 Jan 1;144(1):160-168

CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies Int J Cancer. 2016 Jan 15;138(2):463-71

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